1,184 research outputs found
4-(4-Bromo-3-methyl-1H-pyrazol-1-yl)-6-(but-3-ynyloxy)pyrimidine
There are two molecules in the asymmetric unit of the title compound, C12H11BrN4O. The dihedral angles between the pyrazole and pyrimidine rings are 1.28 (17) and 1.56 (17)° in the two molecules. In one of the molecules, the but-3-ynyloxy side chain is disordered over two sets of sites in a 0.714 (8):0.286 (8) ratio
主在并[a] 龍財赤子愛腔蚓錢粒体編研基因衰退影蝸
The earthworm Eisenia fetida\u27s benzo [a] pyrene (BaP) exposure experiments were carried out in artificial soil according to ISO 11268-1:1993. And then the upregulated and downregulated subtractive cDNA libraries were constructed by Clontech PCR-Select cDNA Subtration Kit. From the BaP exposure upregulated subtractive cDNA library, several cDNA segments matched mitochondrion-encoded genes were found, including cytochrome c oxidase subunit I (CO I), subunit II (CO II), subunit Ill (CO III), NADH dehydrogenase subunit 1 (NDH1), and ATP synthase subunit 6. The result indicated BaP and the subsequent oxidative stress disturbed the expression of mitochondrion-encoded genes, and this was potential biomarker for oxidative stress following xenobiotic exposure.<br /
Design & Optimization of the HV divider for JUNO 20-inch PMT
The Jiangmen Underground Observatory (JUNO) is a 20-kton liquid scintillator
detector that employs 20,000 20-inch photomultiplier tubes (PMTs) as photon
sensors, with 5,000 dynode-PMTs from HAMAMATSU Photonics K.K. (HPK), and 15,000
MCP-PMTs from North Night Vision Technology (NNVT) installed in pure water.
JUNO aims to provide long-lasting and the best performance operation by
utilizing a high-transparency liquid scintillator, high detection efficiency
PMTs, and specially designed electronics including water-proof potting for the
high voltage (HV) dividers of PMTs. In this paper, we present a summary of the
design and optimization of HV dividers for both types of 20-inch PMTs, which
includes collection efficiency, charge resolution, HV divider current, pulse
shape, and maximum amplitude restriction. We have developed and finalized four
schemes of the HV divider for different scenarios, including the final version
selected by JUNO. All 20,000 20-inch PMTs have successfully undergone
production and burning tests.Comment: 14pages,28figure
A simulation study on the measurement of D0-D0bar mixing parameter y at BES-III
We established a method on measuring the \dzdzb mixing parameter for
BESIII experiment at the BEPCII collider. In this method, the doubly
tagged events, with one decays to
CP-eigenstates and the other decays semileptonically, are used to
reconstruct the signals. Since this analysis requires good separation,
a likelihood approach, which combines the , time of flight and the
electromagnetic shower detectors information, is used for particle
identification. We estimate the sensitivity of the measurement of to be
0.007 based on a fully simulated MC sample.Comment: 6 pages, 7 figure
The Role of Molecular Biology in the Biomonitoring of Human Exposure to Chemicals
Exposure to different substances in an occupational environment is of utmost concern to global agencies such as the World Health Organization and the International Labour Organization. Interest in improving work health conditions, particularly of those employees exposed to noxious chemicals, has increased considerably and has stimulated the search for new, more specific and selective tests. Recently, the field of molecular biology has been indicated as an alternative technique for monitoring personnel while evaluating work-related pathologies. Originally, occupational exposure to environmental toxicants was assessed using biochemical techniques to determine the presence of higher concentrations of toxic compounds in blood, urine, or other fluids or tissues; results were used to evaluate potential health risk. However, this approach only estimates the presence of a noxious chemical and its effects, but does not prevent or diminish the risk. Molecular biology methods have become very useful in occupational medicine to provide more accurate and opportune diagnostics. In this review, we discuss the role of the following common techniques: (1) Use of cell cultures; (2) evaluation of gene expression; (3) the “omic” sciences (genomics, transcriptomics, proteomics and metabolomics) and (4) bioinformatics. We suggest that molecular biology has many applications in occupational health where the data can be applied to general environmental conditions
The application of radiomics in esophageal cancer: Predicting the response after neoadjuvant therapy
Esophageal cancer (EC) is one of the fatal malignant neoplasms worldwide. Neoadjuvant therapy (NAT) combined with surgery has become the standard treatment for locally advanced EC. However, the treatment efficacy for patients with EC who received NAT varies from patient to patient. Currently, the evaluation of efficacy after NAT for EC lacks accurate and uniform criteria. Radiomics is a multi-parameter quantitative approach for developing medical imaging in the era of precision medicine and has provided a novel view of medical images. As a non-invasive image analysis method, radiomics is an inevitable trend in NAT efficacy prediction and prognosis classification of EC by analyzing the high-throughput imaging features of lesions extracted from medical images. In this literature review, we discuss the definition and workflow of radiomics, the advances in efficacy prediction after NAT, and the current application of radiomics for predicting efficacy after NAT
Broad-line region in NGC 4151 monitored by two decades of reverberation mapping campaigns. I. Evolution of structure and kinematics
We report the results of long-term reverberation mapping (RM) campaigns of
the nearby active galactic nuclei (AGN) NGC 4151, spanning from 1994 to 2022,
based on archived observations of the FAST Spectrograph Publicly Archived
Programs and our new observations with the 2.3m telescope at the Wyoming
Infrared Observatory. We reduce and calibrate all the spectra in a consistent
way, and derive light curves of the broad H line and 5100\,{\AA}
continuum. Continuum light curves are also constructed using public archival
photometric data to increase sampling cadences. We subtract the host galaxy
contamination using {\it HST} imaging to correct fluxes of the calibrated light
curves. Utilizing the long-term archival photometric data, we complete the
absolute flux-calibration of the AGN continuum. We find that the H time
delays are correlated with the 5100\,{\AA} luminosities as . This is remarkably consistent with
Bentz et al. (2013)'s global size-luminosity relationship of AGNs. Moreover,
the data sets for five of the seasons allow us to obtain the velocity-resolved
delays of the H line, showing diverse structures (outflows, inflows and
disks). Combining our results with previous independent measurements, we find
the measured dynamics of the H broad-line region (BLR) are possibly
related to the long-term trend of the luminosity. There is also a possible
additional 1.86 years time lag between the variation in BLR radius and
luminosity. These results suggest that dynamical changes in the BLR may be
driven by the effects of radiation pressure.Comment: Accepted for publication in MNRAS; comments welcome
Genomewide association study of leprosy.
BACKGROUND: The narrow host range of Mycobacterium leprae and the fact that it is refractory to growth in culture has limited research on and the biologic understanding of leprosy. Host genetic factors are thought to influence susceptibility to infection as well as disease progression. METHODS: We performed a two-stage genomewide association study by genotyping 706 patients and 1225 controls using the Human610-Quad BeadChip (Illumina). We then tested three independent replication sets for an association between the presence of leprosy and 93 single-nucleotide polymorphisms (SNPs) that were most strongly associated with the disease in the genomewide association study. Together, these replication sets comprised 3254 patients and 5955 controls. We also carried out tests of heterogeneity of the associations (or lack thereof) between these 93 SNPs and disease, stratified according to clinical subtype (multibacillary vs. paucibacillary). RESULTS: We observed a significant association (P<1.00x10(-10)) between SNPs in the genes CCDC122, C13orf31, NOD2, TNFSF15, HLA-DR, and RIPK2 and a trend toward an association (P=5.10x10(-5)) with a SNP in LRRK2. The associations between the SNPs in C13orf31, LRRK2, NOD2, and RIPK2 and multibacillary leprosy were stronger than the associations between these SNPs and paucibacillary leprosy. CONCLUSIONS: Variants of genes in the NOD2-mediated signaling pathway (which regulates the innate immune response) are associated with susceptibility to infection with M. leprae
Measurement of the cross-section and charge asymmetry of bosons produced in proton-proton collisions at TeV with the ATLAS detector
This paper presents measurements of the and cross-sections and the associated charge asymmetry as a
function of the absolute pseudorapidity of the decay muon. The data were
collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with
the ATLAS experiment at the LHC and correspond to a total integrated luminosity
of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements
varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the
1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured
with an uncertainty between 0.002 and 0.003. The results are compared with
predictions based on next-to-next-to-leading-order calculations with various
parton distribution functions and have the sensitivity to discriminate between
them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables,
submitted to EPJC. All figures including auxiliary figures are available at
https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13
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